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Study identifier: NCT04989725 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Stereotactic Ablative Radiotherapy for Oligo-Progressive Disease REfractory to Systemic Therapy in Metastatic Cancer

Condition: Metastatic Cancer · Oligoprogressive  ·  Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

PhasePhase 2
Planned participants46
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A registry-based randomized phase II trial. A total of 46 patients with metastatic cancer on systemic therapy with oligoprogression to 1-5 extracranial lesions will be randomized using a 1:1 ratio to standard of care (begin next-line systemic therapy, best supportive care, continue current systemic line, based on treating physician decision) vs. receive stereotactic ablative radiotherapy to all oligoprogressive lesions while continuing their current systemic therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Silvine Benth  ·  514-890-8254  ·  silvine.benth.chum@ssss.gouv.qc.ca

Mom Phat  ·  514-890-8254  ·  mom.phat.chum@ssss.gouv.qc.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Centre Hospitalier de l'Université de MontréalMontreal, Quebec, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT04989725