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Study identifier: NCT04965064 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling

Condition: Breast Cancer  ·  Sponsor: University of Rochester

PhasePhase 2
Planned participants22
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this research is to look at the safety and effectiveness of a HER2-targeted therapy neratinib when given with capecitabine, a chemotherapy, for breast cancer patients with brain metastases whose tumors were HER2-negative by standard tests but showed abnormal HER2 activity based on the CELsignia results.

This description comes directly from the study's public registry record.

Talk to the study team

Jamie Littleton  ·  (585) 273-1507  ·  WCICTOResearch@URMC.Rochester.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of RochesterRochester, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04965064