Condition: Acetaminophen · Drug-Induced Liver Injury · Pharmacogenetics · Sponsor: The First Affiliated Hospital with Nanjing Medical University
Acetaminophen (APAP) is the most commonly used NSAIDS in clinic, and it is also a common cause of drug-induced liver injury (DILI). In 2012, the proportion of DILI caused by APAP in the United States was 51%, while in Asia, it was only 7.10%. Previously, a small cohort study in the United States screened for some of the susceptibility genes for DILI due to APAP by the Genome wide association study (GWAS) method. However, the genetic susceptibility loci based on the US cohort were not applicable to the Chinese population. Therefore, we make a study design include Chinese population who ingested APAP and divided them into case group and control group according to the occurrence of DILI. We hope to be able to find the root of differences at the genetic level and explore new pathogenic mechanisms.
This description comes directly from the study's public registry record.
Hao Sun, professor · 13584017821 · haosun@njmu.edu.cn
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| The First Affiliated Hospital with Nanjing Medical University | Nanjing, Jiangsu, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04964310