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Study identifier: NCT04959474 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

Condition: Anatomic Stage 0 Breast Cancer AJCC v8 · Anatomic Stage 1 Breast Cancer AJCC v8 · Anatomic Stage 2 Breast Cancer AJCC v8  ·  Sponsor: Thomas Jefferson University

PhaseNA
Planned participants80
Who can joinAll sexes, 40 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial studies the effect of calorie reduction while undergoing stereotactic ablative radiation therapy in treating patients with breast cancer. Stereotactic ablative radiation therapy (sABR) is a highly focused radiation treatment that gives an intense dose of radiation concentrated on a tumor, while limiting the dose to the surrounding organ. Giving SABR before surgery may make the tumor smaller. Adding dietary restrictions in combination with radiation therapy may help increase local control and decrease the spread of the cancer to other places in the body. The purpose of this trial is to identify if there is a decrease in tumor tissue in patients undergoing caloric restriction during pre-operative SABR, compared to patients undergoing pre-operative SABR alone.

This description comes directly from the study's public registry record.

Talk to the study team

Nicole Simone, MD  ·  215-955-8874  ·  Nicole.Simone@jefferson.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Thomas Jefferson University HospitalPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04959474