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Study identifier: NCT04952753 Synced from ClinicalTrials.gov · July 28, 2026
● Terminated

Study of NIS793 and Other Novel Investigational Combinations With SOC Anti-cancer Therapy for the 2L Treatment of mCRC

Condition: Metastatic Colorectal Cancer  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 2
Planned participants204
Who can joinAll sexes, 18 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the preliminary efficacy and safety of NIS793 and other novel investigational combinations with standard of care (SOC) anti-cancer therapy vs SOC anti-cancer therapy for the second line treatment of mCRC. This study aims to explore whether different mechanisms of action may reverse resistance and improve responsiveness to the currently considered SOC anti-cancer therapy in the second line metastatic colorectal cancer (mCRC) setting.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (55)

The Angeles Clinic and Research InstituteLos Angeles, California, United States
University of Michigan MedicalAnn Arbor, Michigan, United States
WA Uni School Of MedSt Louis, Missouri, United States
Astera Cancer CenterEast Brunswick, New Jersey, United States
Sarah Cannon Research InstituteNashville, Tennessee, United States
Uni Of TX MD Anderson Cancer CntrHouston, Texas, United States
Mays Cancer CenterSan Antonio, Texas, United States
Novartis Investigative SiteAdelaide, South Australia, Australia
Novartis Investigative SiteBendigo, Victoria, Australia
Novartis Investigative SitePerth, Western Australia, Australia
Novartis Investigative SiteBrussels, Belgium
Novartis Investigative SiteBrussels, Belgium

+ 43 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04952753