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Study identifier: NCT04946370 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

Condition: Prostate Cancer  ·  Sponsor: Weill Medical College of Cornell University

PhasePhase 1/Phase 2
Planned participants52
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase I/II study investigating the combination of 225Ac-J591 (a drug that can deliver radiation to prostate cancer cells) with pembrolizumab (immunotherapy, a drug that increases the immune system's ability to destroy cancer cells). This study will assess whether 225Ac-J591 + pembrolizumab + androgen receptor inhibitor (ARI) is more effective against prostate cancer than pembrolizumab + ARI alone.

This description comes directly from the study's public registry record.

Talk to the study team

GUONC Research Team  ·  212-746-1480  ·  guonc@med.cornell.edu

GUCLINIC Research Team  ·  guclinic@med.cornell.edu

Always discuss trial participation with your own doctor first.

Locations (4)

Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesNot Yet Recruiting
New York Presbyterian/Brooklyn Methodist HospitalBrooklyn, New York, United StatesRecruiting
New York Presbyterian/Weill Cornell Medical CenterNew York, New York, United StatesRecruiting
Columbia University Irving Cancer CenterNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04946370