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Study identifier: NCT04941599 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

Condition: Familial Hypercholesterolemia  ·  Sponsor: Vanderbilt University Medical Center

PhasePhase 2
Planned participants72
Who can joinAll sexes, 18 Years to 69 Years
Healthy volunteersNo

About this study

The Investigators will test the hypothesis that 2-HOBA will reduce modification of HDL and LDL and improve HDL function in humans with heterozygous FH. The Investigators plan to first study subjects with Familial Hypercholesterolemia (FH), treating them with 750 mg of 2-HOBA or placebo every 8 hours for 6 weeks.

This description comes directly from the study's public registry record.

Talk to the study team

Anca Ifrim, RN  ·  6155224210  ·  anca.ifrim@vumc.org

Always discuss trial participation with your own doctor first.

Locations (1)

Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04941599