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Study identifier: NCT04939935 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

Condition: Autosomal Dominant Polycystic Kidney Disease  ·  Sponsor: The University of Queensland

PhasePhase 3
Planned participants1174
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

This study will investigate if a medication (metformin) widely used in the treatment of diabetes could be re-purposed for the treatment of patients with a diagnosis of early stage ADPKD to slow the rate of kidney function decline, reducing morbidity and mortality and improving the quality of life for ADPKD patients.

This description comes directly from the study's public registry record.

Talk to the study team

Misa Matsuyama, PhD  ·  +61 437 759 894  ·  impedepkd@uq.edu.au

Pushparaj Velayudham  ·  +61 438 077 278  ·  impedepkd@uq.edu.au

Always discuss trial participation with your own doctor first.

Locations (49)

Renal ResearchGosford, New South Wales, AustraliaActive Not Recruiting
Royal Prince Alfred HospitalSydney, New South Wales, AustraliaActive Not Recruiting
Royal North Shore HospitalSydney, New South Wales, AustraliaActive Not Recruiting
Westmead Hospital - Western Sydney Local Health DistrictSydney, New South Wales, AustraliaActive Not Recruiting
Bundaberg HospitalBundaberg, Queensland, AustraliaActive Not Recruiting
Townsville University HospitalDouglas, Queensland, AustraliaActive Not Recruiting
Royal Brisbane and Women's HospitalHerston, Queensland, AustraliaActive Not Recruiting
Princess Alexandra HospitalWoolloongabba, Queensland, AustraliaActive Not Recruiting
Royal Adelaide HospitalAdelaide, South Australia, AustraliaActive Not Recruiting
Royal Melbourne HospitalMelbourne, Victoria, AustraliaActive Not Recruiting
Austin HealthMelbourne, Victoria, AustraliaActive Not Recruiting
Monash Medical CentreMelbourne, Victoria, AustraliaActive Not Recruiting

+ 37 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04939935