Condition: Coronary Artery Disease · Sponsor: St. Antonius Hospital
Yearly, 180 000 patients in the Netherlands are referred to a cardiologist with symptoms suspected of coronary artery disease (CAD). To assess this, multiple diagnostic tests are available. Non-invasive imaging tests, such as coronary CT-scan, are safe, relatively cheap and can effectively rule-out CAD. However, when CAD is present, coronary CT-scan cannot assess the restriction in blood flow caused by the stenosis. Cardiac angiography with invasive blood flow measurements is required to assess this restriction in blood flow. This is an invasive test, more expensive than CT and it is accompanied by certain risks. Most patients in whom CAD is present do not need treatment, and would therefore benefit from non-invasive diagnostic tests. To reduce the number of unnecessary cardiac angiography with flow measurements, new imaging techniques have been developed. These techniques use CT- or angiographic images to calculate the restriction in coronary blood flow and determine the need for treatment. This study is designed to assess the safety and efficacy of these techniques when used as an addition to coronary CT-scan. Subjects are eligible if their CT-scan indicates possibly significant CAD. To determine need for treatment of a subject's CAD, the investigators will randomize subjects in three arms. One arm consists of additional CT-derived calculation of coronary blood flow, one arm consists of angiography-derived calculation of coronary blood flow and one arm consists of standar…
This description comes directly from the study's public registry record.
Martin J Swaans, Dr. · +31 (0)88 320 0900 · m.swaans@antoniusziekenhuis.nl
Mike Bosschaert, Drs. · +31 (0)88 320 0900 · m.bosschaert@antoniusziekenhuis.nl
Always discuss trial participation with your own doctor first.
| Catharina Hospital | Eindhoven, North Brabant, Netherlands | Recruiting |
| Maasstad Hospital | Rotterdam, South Holland, Netherlands | Recruiting |
| St. Antonius Hospital | Nieuwegein, Utrecht, Netherlands | Recruiting |
| UMC Utrecht | Utrecht, Utrecht, Netherlands | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT04939207