Condition: Cannabis Use · Major Depressive Disorder · Cognitive Impairment · Sponsor: Centre for Addiction and Mental Health
The prevalence of major depressive disorder (MDD) is \~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold compared to 2.9% in the general population, and is associated with poorer treatment outcomes and impaired cognitive and psychosocial functioning in comparison to MDD patients without CUD. Most studies of cannabis use in MDD are cross-sectional in design, and therefore causal relationships are unclear. This study investigates the effects of cannabis abstinence over a 28-day period in patients with MDD with co-occurring CUD using a randomized controlled design, namely contingent reinforcement.
This description comes directly from the study's public registry record.
Maryam Sorkhou, HBSc · 4165358501 · maryam.sorkhou@mail.utoronto.ca
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| Centre for Addiction and Mental Health | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04935619