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Study identifier: NCT04933669 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors

Condition: Progression-free Survival · Gastrointestinal Stromal Tumor · Neoadjuvant  ·  Sponsor: First Affiliated Hospital of Zhejiang University

PhasePhase 2
Planned participants122
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The R0 resection rate of gastrointestinal stromal tumor (GIST) with high recurrence risk was relatively low, and the relapse-free survival rate was relatively low, which needed to be further improved. A few retrospective analyses and a small sample of prospective studies have found that neoadjuvant therapy with imatinib mesylate can improve R0 resection rates. Whether neoadjuvant therapy prolongs long-term survival remains unclear. The primary objective of this study was to evaluate 5-year progression-free survival (PFS) for GIST patients with high recurrence risk after neoadjuvant treatment with imatinib mesylate.

This description comes directly from the study's public registry record.

Talk to the study team

Weili Yang, Doctor  ·  +8613989879196  ·  yangweili@zju.edu.cn

Jiren Yu  ·  +8657187236147  ·  yujr0909@zju.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

The First Affiliated Hospital, College of Medicine, Zhejiang UniversityHangzhou, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT04933669