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Study identifier: NCT04929223 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Condition: Metastatic Colorectal Cancer  ·  Sponsor: Hoffmann-La Roche

PhasePhase 1
Planned participants542
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combinations, in participants with metastatic colorectal cancer (mCRC) whose tumors are biomarker positive as per treatment arm-specific definition. Eligible participants with mCRC will be enrolled into specific treatment arms based on their biomarker assay results.

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: WO42758 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S. and Canada)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (84)

UAB Comprehensive Cancer CenterBirmingham, Alabama, United StatesWithdrawn
Mayo Clinic ArizonaPhoenix, Arizona, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
cCareEncinitas, California, United StatesWithdrawn
USC Norris Cancer CenterLos Angeles, California, United StatesCompleted
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
UCLALos Angeles, California, United StatesRecruiting
Hoag Memorial Hospital PresbyterianNewport Beach, California, United StatesWithdrawn
Stanford Cancer CenterStanford, California, United StatesCompleted
University of Colorado Cancer CenterAurora, Colorado, United StatesRecruiting
Rocky Mountain Cancer Centers, LLPLone Tree, Colorado, United StatesRecruiting
Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting

+ 72 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04929223