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Study identifier: NCT04925479 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

Condition: Myeloid Leukemia, Philadelphia Positive  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants34
Who can joinAll sexes, 1 Year to 17 Years
Healthy volunteersNo

About this study

The aim of this study is to support development of asciminib in the pediatric population (1 to \<18 years) previously treated with one or more TKIs. Full extrapolation of the efficacy of asciminib from adult to pediatric patients will be conducted. Full extrapolation is based on the concept that CML in the pediatric population has the same pathogenesis, similar clinical characteristics and progression pattern as in adults.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111

Always discuss trial participation with your own doctor first.

Locations (39)

Indiana UH Riley H for CIUIndianapolis, Indiana, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
University of Mississippi Medical CenterJackson, Mississippi, United StatesRecruiting
Columbia University Medical Center New York PresbyterianNew York, New York, United StatesRecruiting
Cinn Children Hosp Medical CenterCincinnati, Ohio, United StatesRecruiting
Childrens Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
Uni Of Texas MD Anderson Cancer CtrHouston, Texas, United StatesRecruiting
University Of UtahSalt Lake City, Utah, United StatesRecruiting
Novartis Investigative SiteHangzhou, Zhejiang, ChinaRecruiting
Novartis Investigative SiteBeijing, ChinaRecruiting
Novartis Investigative SiteShanghai, ChinaRecruiting
Novartis Investigative SiteTianjin, ChinaRecruiting

+ 27 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04925479