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Study identifier: NCT04925375 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

Condition: Interstitial Lung Disease · Common Variable Immunodeficiency  ·  Sponsor: Children's Hospital Medical Center, Cincinnati

PhasePhase 2
Planned participants38
Who can joinAll sexes, 4 Years to no upper limit
Healthy volunteersNo

About this study

There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked promising for the treatment of patients with complex CVID. This study is a multi-site, phase II, randomized, blinded/placebo-controlled clinical trial in pediatric and adult subjects to determine the efficacy of abatacept compared to placebo for treatment of subjects with GLILD in the context of CVID. Funding Source - FDA OOPD

This description comes directly from the study's public registry record.

Talk to the study team

Michael Jordan  ·  513-803-9063  ·  Michael.Jordan.@cchmc.org

Always discuss trial participation with your own doctor first.

Locations (6)

University of California, San FranciscoSan Francisco, California, United StatesRecruiting
University of South FloridaTampa, Florida, United StatesRecruiting
Lahey Hospital and Medical CenterBurlington, Massachusetts, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting
Duke University Health SystemDurham, North Carolina, United StatesRecruiting
Cincinnati Children's Hospital Medical CenterCincinnati, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04925375