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Study identifier: NCT04913805 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Matching Perfusion and Metabolic Activity in HFpEF

Condition: Heart Failure With Preserved Ejection Fraction  ·  Sponsor: University of Pennsylvania

PhasePhase 2
Planned participants53
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will test whether pharmacologic agents that increase perfusion \[Potassium Nitrate (KNO3)\], with and without additional supplements that may improve mitochondrial function \[Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).

This description comes directly from the study's public registry record.

Talk to the study team

Melissa Fernand, MPH  ·  2672536141  ·  fernand@pennmedicine.upenn.edu

Cassandra Demastus, NP  ·  4432719022  ·  Cassandra.Demastus@Pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04913805