Condition: Acute Respiratory Failure With Hypoxia · Sponsor: Jesus Villar
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support. In 1975, several investigators published the effects of PEEP in 15 mechanically ventilated patients with acute respiratory failure (ARF) supported by mechanical ventilation. FiO2 ranged between 21% to 75% and the tidal volume between 13 to 15 mL/kg. PEEP was increased in 3 cmH2O steps until cardiac output fell. The aim was to identify the "optimum" PEEP level. "Best" PEEP was associated simultaneously with the best static compliance of the respiratory system, the greatest oxygen transport, and the lowest dead space fraction. That study established the basis for the use of PEEP in patients with ARF worldwide. Although currently patients with ARF are ventilated with much lower tidal volumes, that study has never been validated. It is unknow whether their findings are currently valid, generalizable, and reproducible.
This description comes directly from the study's public registry record.
Jesús Villar, MD · +34606860027 · jesus.villar54@gmail.com
Angel Becerra, MD · +34676229025 · ang_bcr.bol@hotmail.com
Always discuss trial participation with your own doctor first.
| Hospital Universitario Dr. Negrin | Las Palmas de Gran Canaria, Las Palmas, Spain | Recruiting |
| Hospital Clinic | Barcelona, Spain | Not Yet Recruiting |
| Hospital Universitario La Princesa | Madrid, Spain | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT04912960