Condition: Chronic Kidney Diseases · Hypertension · Aging · Sponsor: University of Colorado, Denver
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control \<130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug therapy is recommended to lower blood pressure; however, adherence to time-intensive lifestyle interventions such as aerobic exercise in patients with chronic kidney disease is poor. This clinical trial seeks to establish the efficacy of high-resistance inspiratory muscle strength training, a novel time-efficient lifestyle intervention, for lowering systolic blood pressure and improving endothelial function in midlife and older adults with moderate-to-severe chronic kidney disease and inadequately controlled hypertension, and to use innovate translational assessments to understand the mechanisms involved.
This description comes directly from the study's public registry record.
Kristen Nowak, PhD, MPH · 303-724-4842 · Kristen.Nowak@cuanschutz.edu
Emily Andrews · 303-724-7790
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| University of Colorado - Anschutz Medical Campus | Aurora, Colorado, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04911491