Condition: Pulmonary Hypertension · Sponsor: University Health Network, Toronto
Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the cancer DNA. PET/MR as imaging biomarkers for cardiopulmonary dysfunction with a focus on Pulmonary hypertension (PH). Despite the measures taken to reduce the total radiation dose and to limit the radiation to normal tissues, there is evidence of transient or permanent radiotherapy induced myocardial and pulmonary dysfunction leading to PH in patients who receive radiotherapy above a certain threshold of received dose. To be able to Demonstrate correlation of combined PET/MR and plasma metabolomics markers in patients at risk of developing cardiopulmonary disfunction after RT.
This description comes directly from the study's public registry record.
Patrick Veit-Haibach, MD · 416-340-4800 · Patrick.Veit-Haibach@uhn.ca
Andrew Hope, MD · 416-946-2124 · Andrew.Hope@rmp.uhn.ca
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| University Health Network | Toronto, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04901884