Condition: Opioid-use Disorder · Sponsor: University of British Columbia
This is a multi-centre, open-label RCT at four Emergency Departments (EDs) in British Columbia and Alberta. The purpose of the current study is to compare the effectiveness of buprenorphine/naloxone microdosing and standard dosing take-home induction regimens at enabling patients to successfully complete the induction regimen, and at retaining patients on opioid agonist therapy. We will randomize our enrolled patients to receive take-home microdosing or standard dosing packages of buprenorphine/naloxone. For the microdosing arm, patients immediately start taking low doses that increase to effective levels without requiring them to go into withdrawal. We hypothesize that ED patients provided buprenorphine/naloxone microdosing packages will be more likely to successfully complete the induction period compare to patients provided standard dosing packages. We furthermore hypothesize that those provided microdosing will be more likely to be retained in opioid agonist therapy, and will experience lower overdose, mortality, and healthcare utilization subsequent to their ED visit.
This description comes directly from the study's public registry record.
Elle Wang, MSc · 6046152538 · seth.long@ubc.ca
Cindy Liu, BSc · 778-929-1281 · elle.wang@ubc.ca
Always discuss trial participation with your own doctor first.
| Foothills Medical Centre | Calgary, Alberta, Canada | Recruiting |
| Northeast Community Health Centre | Edmonton, Alberta, Canada | Recruiting |
| Royal Alexandra Hospital | Edmonton, Alberta, Canada | Not Yet Recruiting |
| Vancouver General Hospital | Vancouver, British Columbia, Canada | Recruiting |
| University of British Columbia Hospital | Vancouver, British Columbia, Canada | Recruiting |
| St. Paul's Hospital | Vancouver, British Columbia, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04893525