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Study identifier: NCT04893109 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

ATEMPT 2.0: Adjuvant T-DM1 vs TH

Condition: Breast Cancer · HER2-positive Breast Cancer  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 2
Planned participants500
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is studying how well newly diagnosed breast cancer that has tested positive for a protein called HER2 responds using one of two different combination of HER2-directed therapies as a treatment after surgery. The name of the study drugs involved are: * Trastuzumab-emtansine (T-DM1, Kadcyla) * Trastuzumab SC (Herceptin Hylecta) * Paclitaxel

This description comes directly from the study's public registry record.

Talk to the study team

Sara Tolaney, MD, PhD  ·  617-632-2335  ·  sara_tolaney@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (53)

UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, California, United StatesRecruiting
Smilow Cancer Hospital Care center at DerbyDerby, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at FairfieldFairfield, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at GlastonburyGlastonbury, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at GreenwichGreenwich, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at GuilfordGuilford, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at St. FrancisHartford, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at Long RidgeLong Ridge, Connecticut, United StatesRecruiting
Yale Cancer Center at Yale University School of MedicineNew Haven, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at North HavenNorth Haven, Connecticut, United StatesRecruiting
Stamford HospitalStamford, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care center at TorringtonTorrington, Connecticut, United StatesRecruiting

+ 41 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04893109