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Study identifier: NCT04891289 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery

Condition: Intrahepatic Cholangiocarcinoma  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants164
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will compare the safety and effects of HAI floxuridine and dexamethasone combined with the standard chemotherapy drugs gemcitabine and oxaliplatin (GemOx) with those of GemOx alone in people with untreated cholangiocarcinoma that cannot be removed with surgery. The researchers want to find out whether the study treatment works better than the standard chemotherapy to delay progression of disease. For the study treatment to be considered better than the standard treatment, the study treatment should increase the time until progression of disease by an average of 3 months, compared with the usual approach.

This description comes directly from the study's public registry record.

Talk to the study team

Andrea Cercek, MD  ·  646-888-4189  ·  cerceka@mskcc.org

William Jarnagin, MD  ·  212-639-7601

Always discuss trial participation with your own doctor first.

Locations (11)

National Heart, Lung, and Blood Institute (NIH) (Data Collection Only)Bethesda, Maryland, United StatesRecruiting
Washington University (Data Collection Only)St Louis, Missouri, United StatesRecruiting
Memorial Sloan Kettering Basking Ridge - Limited Protocol ActivitiesBasking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth - Limited Protocol ActivitiesMiddletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen - Limited Protocol ActivitiesMontvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Commack - Limited Protocol ActivitiesCommack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester - Limited Protocol ActivitiesHarrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau - Limited Protocol ActivitiesUniondale, New York, United StatesRecruiting
Duke University (Data Collection Only)Durham, North Carolina, United StatesRecruiting
Erasmus University (Data Collection Only)Rotterdam, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT04891289