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Study identifier: NCT04886986 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase I Study of 225Ac-J591 Plus 177Lu-PSMA Small Molecule for Progressive Metastatic Castration Resistant Prostate Cancer

Condition: Prostate Cancer  ·  Sponsor: Weill Medical College of Cornell University

PhasePhase 1
Planned participants42
Who can joinMale, 18 Years to 99 Years
Healthy volunteersNo

About this study

This is a phase I dose-escalation study of 225Ac-J591 administered together with 177Lu-PSMA small molecule. Both drugs are designed to deliver radiation to prostate cancer cells; they are known as radionuclide conjugates (radiation linked to antibodies/molecules that recognize prostate cancer cells). This phase of the study (phase I) will determine the highest dose of the study intervention that can be safely given.

This description comes directly from the study's public registry record.

Talk to the study team

GUONC Research Team  ·  212-746-1480  ·  guonc@med.cornell.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Brooklyn Methodist Hospital - New York PresbyterianBrooklyn, New York, United StatesRecruiting
Weill Cornell Medicine New York PresbyterianNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04886986