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Study identifier: NCT04879329 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

Condition: Urothelial Carcinoma  ·  Sponsor: Seagen, a wholly owned subsidiary of Pfizer

PhasePhase 2
Planned participants372
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being done to see if a drug called disitamab vedotin, alone or with pembrolizumab, works to treat HER2 expressing urothelial cancer. It will also test how safe the drug is for participants. Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic). It will also study what side effects happen when participants get the drug. A side effect is anything a drug does to your body besides treating the disease.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (221)

Banner Gateway Medical CenterGilbert, Arizona, United StatesRecruiting
Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
Kaiser Permanente Anaheim Kraemer Medical OfficesAnaheim, California, United StatesRecruiting
Foothill CardioologyArcadia, California, United StatesRecruiting
Kaiser Permanente Baldwin Park Medical CenterBaldwin Park, California, United StatesRecruiting
Kaiser Permanente Bellflower Medical OfficesBellflower, California, United StatesRecruiting
Beverly Hills Multi-Specialties PracticeBeverly Hills, California, United StatesRecruiting
Providence Saint Joseph Medical CenterBurbank, California, United StatesRecruiting
UCLA Burbank CardiologyBurbank, California, United StatesRecruiting
UCLA Hematology/Oncology - BurbankBurbank, California, United StatesRecruiting
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)Duarte, California, United StatesActive Not Recruiting
UCLA Encino Specialty Care (Radiology)Encino, California, United StatesRecruiting

+ 209 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04879329