Condition: Complicated Urinary Tract Infection · Infection · Pediatric Infectious Disease · Sponsor: Murdoch Childrens Research Institute
Urinary tract infections (UTI) are commonly encountered in children, with 7% diagnosed with at least one UTI by the age of 19 years. The evidence for treatment of uncomplicated UTI is clear; oral antibiotics are as good as intravenous (IV) antibiotics, usually for a total of 7 days. Complicated UTIs (cUTIs) on the other hand, are common reasons for hospital admissions for IV antibiotics and constitute a major burden for healthcare systems. There is considerable variation in care for children who present with UTI and have complicating features such as vomiting, dehydration, urological abnormalities or have a previous history of UTI. Australian and international guidelines lack clear, evidence-based recommendations to guide treatment in this group. Without gold standard evidence, these children will continue to receive unnecessary IV antibiotics, longer hospital stays and poorer health outcomes. This multicentre, non-inferiority randomised trial will investigate if One dose - single dose of IV followed by 2 days oral antibiotics is as non-inferior to Three doses for children with UTI and co-existing complicating factors presenting to the Emergency Department (ED). In other words, this study will compare if a single dose of IV antibiotics plus two days oral antibiotics is as clinically effective as 3 doses antibiotics in resolving UTI symptoms at 72 hours after the first dose of IV antibiotics, for complicated UTIs in children presenting to the ED. All participants will receive…
This description comes directly from the study's public registry record.
Laila Ibrahim · +61401765546 · laila.ibrahim@mcri.edu.au
Lucy Hill · +61383416200 · lucy.hill@mcri.edu.au
Always discuss trial participation with your own doctor first.
| Flinders Medical Centre | Adelaide, South Australia, Australia | Recruiting |
| Women and Children's Hospital | Adelaide, South Australia, Australia | Recruiting |
| University Hospital Geelong | Geelong, Victoria, Australia | Recruiting |
| Monash Health | Melbourne, Victoria, Australia | Recruiting |
| Royal Children's Hospital | Parkville, Victoria, Australia | Recruiting |
| Perth Children's Hospital | Perth, Washington, Australia | Recruiting |
| Starship Children's Hospital | Auckland, Auckland Province, New Zealand | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04876131