Condition: Malignant Peripheral Nerve Sheath Tumors (MPNST) · Sponsor: Memorial Sloan Kettering Cancer Center
The purpose of this study is to see whether the study drug ASTX727 is an effective treatment for people who have MPNST with a PCR2 mutation. ASTX727 is a combination of two drugs (cedazuridine and decitabine) that have been designed to target cancer cells with a PCR2 mutation and to disrupt the cells' ability to survive and grow. The study researchers think that the study drug allows decitabine to work better than decitabine given alone.
This description comes directly from the study's public registry record.
Ping Chi, MD, PhD · 646-888-4166 · zzPDL_MED_Sarcoma_Clinical_Trials@mskcc.org
Ciara Kelly, MBBCH BAO · 646-888-4312 · zzPDL_MED_Sarcoma_Clinical_Trials@mskcc.org
Always discuss trial participation with your own doctor first.
| Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) | Basking Ridge, New Jersey, United States | Recruiting |
| Memorial Sloan Kettering Monmouth (Limited Protocol Activities) | Middletown, New Jersey, United States | Recruiting |
| Memorial Sloan Kettering Bergen (Limited Protocol Activities) | Montvale, New Jersey, United States | Recruiting |
| Memorial Sloan Kettering Commack (Limited Protocol Activities) | Commack, New York, United States | Recruiting |
| Memorial Sloan Kettering Westchester (Limited Protocol Activities) | Harrison, New York, United States | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York, New York, United States | Recruiting |
| Memorial Sloan Kettering Nassau (Limited Protocol Activities) | Uniondale, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04872543