Condition: Schizophrenia · Cannabis-Induced Disorder · Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy. Validated care has limited effectiveness in this population and development of new management strategies seems necessary. Transcranial direct current stimulation (tDCS) has shown beneficial effects in both schizophrenia, substance use disorder and, in a less extent, in nicotine addiction in schizophrenic subjects. It is interesting to test if that 10 sessions of anodal stimulation of the right dorsolateral prefrontal cortex (DLPFC) and cathodal stimulation of the medial prefrontal cortex (MPFC) (by increasing control and modulating reward system), will reduce, in 110 schizophrenic subjects, cannabis consumption, and secondly craving, addiction severity, schizophrenic symptoms and improve global functioning. It is possible that these clinical effects will be associated with changes in certain cognitive functions and cerebral connectivity.
This description comes directly from the study's public registry record.
Aurelia GAY, MD · (0)4 77 82 88 50 · aurelia.gay@chu-st-etienne.fr
Béatrice DEYGAS · beatrice.deygas@chu-st-etienne.fr
Always discuss trial participation with your own doctor first.
| CH Le Vinatier Service universitaire d'addictologie de Lyon | Bron, France | Not Yet Recruiting |
| Centre Hospitalier Universitaire Service d'Addictologie et Pathologies Duelles | Clermont-Ferrand, France | Not Yet Recruiting |
| CHU de Clermont-Ferrand Service de Psychiatrie | Clermont-Ferrand, France | Not Yet Recruiting |
| Service Hospitalo-Universitaire d'Addictologie CHU de Dijon | Dijon, France | Not Yet Recruiting |
| CHU Pôle de Psychiatrie Neurologie et Rééducation | La Tronche, France | Not Yet Recruiting |
| CH Saint-Cyr-au-Mont-d'Or service de psychiatrie | Saint-Cyr-au-Mont-d'Or, France | Not Yet Recruiting |
| Centre Hospitalier Alpes Isère | Saint-Égrève, France | Not Yet Recruiting |
| CHU de Saint-Etienne | Saint-Priest-en-Jarez, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04871048