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Study identifier: NCT04858334 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Condition: Pancreatic Acinar Cell Carcinoma · Pancreatic Adenosquamous Carcinoma · Pancreatic Squamous Cell Carcinoma  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 2
Planned participants152
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

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Locations (454)

Anchorage Associates in Radiation MedicineAnchorage, Alaska, United StatesSuspended
Anchorage Radiation Therapy CenterAnchorage, Alaska, United StatesSuspended
Alaska Breast Care and Surgery LLCAnchorage, Alaska, United StatesSuspended
Alaska Oncology and Hematology LLCAnchorage, Alaska, United StatesSuspended
Alaska Women's Cancer CareAnchorage, Alaska, United StatesSuspended
Anchorage Oncology CentreAnchorage, Alaska, United StatesSuspended
Katmai Oncology GroupAnchorage, Alaska, United StatesSuspended
Providence Alaska Medical CenterAnchorage, Alaska, United StatesSuspended
Fairbanks Memorial HospitalFairbanks, Alaska, United StatesSuspended
Kingman Regional Medical CenterKingman, Arizona, United StatesRecruiting
Cancer Center at Saint Joseph'sPhoenix, Arizona, United StatesActive Not Recruiting
Mercy Hospital Fort SmithFort Smith, Arkansas, United StatesSuspended

+ 442 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04858334