Condition: Lymphoplasmacytic Lymphoma · Waldenstrom Macroglobulinemia · Sponsor: National Cancer Institute (NCI)
This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib, a type of tyrosine kinase inhibitor, blocks a protein called BTK, which may help keep cancer cells from growing. Giving venetoclax and rituximab may work better in treating patients with previously untreated Waldenstrom's macroglobulinemia than ibrutinib with rituximab or zanubrutinib alone.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | Recruiting |
| City of Hope at Irvine Lennar | Irvine, California, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Springs | Coral Springs, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Doral | Doral, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood, Florida, United States | Recruiting |
| Mayo Clinic in Florida | Jacksonville, Florida, United States | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami, Florida, United States | Recruiting |
| University of Miami Sylvester Comprehensive Cancer Center at Sole Mia | North Miami, Florida, United States | Recruiting |
+ 124 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04840602