Condition: Bone Neoplasm of Vertebral Column · Chordoma · Chondrosarcoma · Sponsor: Leiden University Medical Center
Rationale: Chordomas and chondrosarcomas located in the axial skeleton are malignant neoplasms of bone. These tumors share the same clinical challenges, as the effect of the disease is more a function of their local aggressiveness than their tendency to metastasize (20% metastasize). The local aggressive behavior can cause debilitating morbidity and mortality by destruction of nearby located critical neurovascular structures. Imaging has, in addition to histopathology, a role in diagnosis and in guiding (neo)adjuvant and definitive treatment. Despite the low sensitivity to radiotherapy, proton radiotherapy has been successfully used as an adjunct to resection or as definitive treatment for aggressive chordomas and chondrosarcomas, making it a standard indication for proton therapy in the Netherlands. Chordomas and chondrosarcomas consist, especially after previous therapy, of non-viable and viable tumor components. Identification of these viable components by functional imaging is important to determine the effect of previous therapy, as change in total tumor volume occurs more than 200 days after change of functional imaging parameters. Objective: The main objective of this study is to determine if functional MRI parameters change within 6 months, and earlier than volumetric changes after start of proton beam therapy. This would allow timely differentiation between affected and unaffected (viable) tumor components, which can be used for therapy adjustment. Secondary objec…
This description comes directly from the study's public registry record.
Stijn Krol, dr. PhD · +31624539398 · A.D.G.Krol@lumc.nl
Vesna Miladinovic · +31682225869 · v.miladinovic@lumc.nl
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| HollandPTC | Delft, South Holland, Netherlands | Recruiting |
| LUMC | Leiden, South Holland, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04832620