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Study identifier: NCT04830137 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Condition: Chronic Lymphocytic Leukemia (CLL) · Small Lymphocytic Lymphoma (SLL) · Waldenstrom Macroglobulinemia (WM)  ·  Sponsor: Nurix Therapeutics, Inc.

PhasePhase 1
Planned participants248
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-2127 in patients with advanced B-cell malignancies.

This description comes directly from the study's public registry record.

Talk to the study team

Patient Outreach  ·  (415)-230-7806  ·  nx2127001@nurixtx.com

Always discuss trial participation with your own doctor first.

Locations (16)

City of HopeDuarte, California, United StatesRecruiting
University of California IrvineOrange, California, United StatesCompleted
University of California San Francisco Medical CenterSan Francisco, California, United StatesCompleted
Sarah Cannon Research Institute at Colorado Blood Cancer InstituteDenver, Colorado, United StatesRecruiting
Mount Sinai Comprehensive Cancer CenterMiami Beach, Florida, United StatesCompleted
Sarah Cannon Research Institute at Florida Cancer SpecialistsSarasota, Florida, United StatesCompleted
The University of Chicago Medical CenterChicago, Illinois, United StatesRecruiting
National Institutes of Health Clinical CenterBethesda, Maryland, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesCompleted
University of Cincinnati Medical CenterCincinnati, Ohio, United StatesCompleted
OSU Wexner Medical CenterColumbus, Ohio, United StatesCompleted
Tennessee OncologyNashville, Tennessee, United StatesRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04830137