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Study identifier: NCT04829708 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy

Condition: Limited Stage Small Cell Lung Cancer  ·  Sponsor: Shandong Cancer Hospital and Institute

PhasePhase 3
Planned participants534
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a prospective, open,multicenter, randomized controlled phase III clinical trial. In patients with LS-SCLC who achieve remission after first-line chemoradiotherapy, the efficacy and safety of PCI or MRI surveillance is evaluated and analyzed. PCI is performed in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. MRI surveillance alone (delaying radiation until the actual brain metastasis) may be not inferior to PCI.

This description comes directly from the study's public registry record.

Talk to the study team

Jinming Yu, PhD  ·  +8613806406293  ·  sdyujinming@126.com

Xiangjiao Meng, PhD  ·  +8613793150996  ·  mengxiangjiao@126.com

Always discuss trial participation with your own doctor first.

Locations (2)

Shandong Cancer Hospital and InstituteJinan, Shandong, ChinaRecruiting
Shandong Cancer HospitalJinan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT04829708