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Study identifier: NCT04819269 Synced from ClinicalTrials.gov · July 27, 2026
● Completed

Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

Condition: Dry Eye Disease · Sjögren Syndrome  ·  Sponsor: Sylentis, S.A.

PhasePhase 3
Planned participants203
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will examine the efficacy and safety of tivanisiran sodium eye drops versus vehicle after a 2-week run-in phase when dosed once daily for 3 months in subjects with signs and symptoms of dry eye disease (DED) due to Sjögren's Syndrome.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (46)

Sylentis Investigative SiteBirmingham, Alabama, United States
Sylentis Investigative SiteDothan, Alabama, United States
Sylentis Investigative SiteScottsdale, Arizona, United States
Sylentis Investigative SiteGarden Grove, California, United States
Sylentis Investigative SiteGlendale, California, United States
Sylentis Investigative SiteLos Angeles, California, United States
Sylentis Investigative SiteNewport Beach, California, United States
Sylentis Investigative SiteRancho Cordova, California, United States
Sylentis Investigative SiteSan Diego, California, United States
Sylentis Investigative SiteTorrance, California, United States
Sylentis Investigative SiteAurora, Colorado, United States
Sylentis Investigative SiteColorado Springs, Colorado, United States

+ 34 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04819269