Condition: Rheumatic Diseases · Mood Disorders · Sponsor: Centre Hospitalier Universitaire de Besancon
Chronic inflammatory rheumatic diseases (CIRD) affect many organ systems. Painful sensations within the joints spine, hand and foot deformities, low quality of life and psychosocial status in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis can lead to the development of anxiety and depression. Prevalences of anxiety increase in patients suffering of CIRD, compared with healthy individuals. Another connection has been identified by the links between depression and systemic inflammation. It is proven that higher plasma levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFa) affect neurotransmitter metabolism, with influence on patients mood. The purpose of EMOTION study is therefore to analyze thymic variation under TNFa therapy, as treatment of CIRDs.
This description comes directly from the study's public registry record.
Charline Vauchy, PhD · +333 81 21 88 75 · cvauchy@chu-besancon.fr
Magali Nicolier-Pallandre, PhD
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| University Hospital | Besançon, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04817072