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Study identifier: NCT04813159 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Remote Ischaemic Conditioning in STEMI Patients in AFRICA

Condition: STEMI · Remote Ischaemic Conditioning · Myocardial Reperfusion Injury  ·  Sponsor: University of Cape Town

PhaseNA
Planned participants1400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The RIC-AFRICA trial is a multi-centre, sham-controlled, randomised controlled trial (RCT) involving 1400 ST-segment elevation myocardial infarction (STEMI) patients presenting within ≤ 24 hours of myocardial infarction (MI) onset, across approximately 25 sites in 7 African countries (South Africa, Kenya, Sudan, Uganda, Mozambique, Senegal and Mauritius). Patients presenting with STEMI and deemed ineligible for the RIC AFRICA RCT because they present \>24 hours from MI onset but less than 72 hours, will be recruited into the observational arm of the study with the same endpoints as the trial. The purpose of the RCT is to determine whether Remote Ischaemic Conditioning (RIC) can reduce the rates of all-cause death and early post-myocardial heart failure at 30-days in STEMI patients treated predominantly with thrombolytic therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Kishal Lukhna, MBChB  ·  +27732515380  ·  kishallukhna@gmail.com

Sara Giesz  ·  +44(0)20 3447 9888  ·  s.giesz@ucl.ac.uk

Always discuss trial participation with your own doctor first.

Locations (20)

Coast General Teaching HospitalMombasa, Mombasa County, KenyaRecruiting
Mombasa HospitalMombasa, Mombasa County, KenyaRecruiting
Kenyatta National HospitalNairobi, Nairobi County, KenyaRecruiting
Nairobi West hospitalNairobi, KenyaRecruiting
Hospital Central de MpautoMaputo, MozambiqueRecruiting
Hopital Principal de DakarDakar, SenegalRecruiting
Charlotte Maxeke HospitalJohannesburg, Gauteng, South AfricaRecruiting
Wentworth HospitalDurban, KwaZulu-Natal, South AfricaRecruiting
Tshepong HospitalKlerksdorp, North West, South AfricaRecruiting
Mitchell's Plain District HospitalCape Town, Western Cape, South AfricaRecruiting
Groote Schuur HospitalCape Town, Western Cape, South AfricaRecruiting
Victoria HospitalCape Town, Western Cape, South AfricaRecruiting

+ 8 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04813159