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Study identifier: NCT04807881 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase Ib Clinical Study of Keynatinib

Condition: Lymphoma, B-Cell  ·  Sponsor: Medolution Ltd.

PhasePhase 1
Planned participants75
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy, safety, PK characteristics in subjects with relapsed/refractory B-cell lymphoma. Furthermore, the relationship between the exposure level of Keynatinib and its efficacy and safety, the penetration rate of keynatinib in the Blood-Brain Barrier (BBB) and its PK characteristics in cerebrospinal fluid in R/R-PCNSL patients, the relationship between the BTK receptor occupancy rate and the efficacy are also evaluated.

This description comes directly from the study's public registry record.

Talk to the study team

Jin Yan, MD  ·  +8618652596381  ·  jin.yan@teligene.com

Always discuss trial participation with your own doctor first.

Locations (4)

Cancer Hospital, Chinese Academy of Medical SciencesBeijing, Beijing Municipality, ChinaNot Yet Recruiting
Peking University Third HospitalBeijing, Beijing Municipality, ChinaRecruiting
Fudan University Shanghai Cancer CenterShanghai, Shanghai Municipality, ChinaRecruiting
West China Hospital,Sichuan UniversityChengdu, Sichuan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT04807881