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Study identifier: NCT04807673 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Pembrolizumab Plus Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiotherapy for Locally Advanced ESCC (KEYSTONE-002)

Condition: Esophageal Squamous Cell Carcinoma  ·  Sponsor: Tianjin Medical University Cancer Institute and Hospital

PhasePhase 3
Planned participants342
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus paclitaxel, cisplatin as neoadjuvant therapy followed by surgery, and pembrolizumab as adjuvant therapy, compared with neoadjuvant chemoradiotherapy and surgery for locally advanced ESCC in multicenter.

This description comes directly from the study's public registry record.

Talk to the study team

Hongjing Jiang, MD,PhD  ·  18622221069  ·  jianghongjing@tmu.edu.cn

Xiaobin Shang, MD,PhD  ·  18622221071  ·  shangxiaobin@tmu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Department of minimally invasive esophageal surgery, Tianjin Medical University Cancer Institute and HospitalTianjin, Tianjin Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT04807673