Condition: Intestinal Transplantation · Sponsor: Columbia University
The purpose of this study is to investigate the safety and feasibility of giving intestinal transplant patients CD34+ stem cells (the cells that make all the types of blood cells) obtained from their organ donor's bone marrow. The goal of this is to develop a post-transplant treatment strategy that controls rejection while reducing the high risk of infection and malignant disease associated with the high levels of immunosuppression medication(s) that intestinal and multi-organ transplant patients must take. Infusion of bone marrow cells from the same donor of the transplanted organ(s) could promote a state called "mixed chimerism" in which both donor cells and recipient cells coexist in the body with the ultimate goal of minimizing the amount of immunosuppression medication(s) needed.
This description comes directly from the study's public registry record.
Clinical Research Core · 212-305-3839 · tk2388@cumc.columbia.edu
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| Columbia University Irving Medical Center/NYP | New York, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04804891