Condition: Metastatic Lung Small Cell Carcinoma · Metastatic Malignant Neoplasm in the Brain · Recurrent Lung Small Cell Carcinoma · Sponsor: NRG Oncology
This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | Active Not Recruiting |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | Recruiting |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | Recruiting |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles, California, United States | Recruiting |
| Los Angeles General Medical Center | Los Angeles, California, United States | Recruiting |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | Recruiting |
| Kaiser Permanente-Ontario | Ontario, California, United States | Recruiting |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Active Not Recruiting |
| UCHealth Memorial Hospital Central | Colorado Springs, Colorado, United States | Active Not Recruiting |
| Memorial Hospital North | Colorado Springs, Colorado, United States | Active Not Recruiting |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich, Connecticut, United States | Terminated |
| Smilow Cancer Hospital Care Center - Guilford | Guilford, Connecticut, United States | Terminated |
+ 219 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04804644