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Study identifier: NCT04792489 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

DALY II USA/ MB-CART2019.1 for DLBCL

Condition: Refractory Diffuse Large B Cell Lymphoma (DLBCL) · Relapsed Diffuse Large B Cell Lymphoma · High Grade B-cell Lymphoma (HGBCL)  ·  Sponsor: Miltenyi Biomedicine GmbH

PhasePhase 2
Planned participants315
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

DALY II USA is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory B cell lymphoma (BCL). Cohorts include subjects with diffuse large B-cell lymphoma (DLBCL) after receiving at least 2 lines of therapy, primary or secondary central nervous system (CNS) lymphoma (PCNSL) and (SCNSL) after receiving at least one line of therapy, mantle cell lymphoma (MCL) and Richter's transformation (RT) after receiving at least one line of therapy, and DLBCL transplant-ineligible after receiving at least one line of therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Ron Gomez  ·  617-218-0044  ·  clinicaltrials@miltenyi.com

Harshita Gahankari  ·  617-218-0044  ·  clinicaltrials@miltenyi.com

Always discuss trial participation with your own doctor first.

Locations (32)

University of Alabama at BirminghamBirmingham, Alabama, United StatesRecruiting
Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
Mayo ClinicPhoenix, Arizona, United StatesRecruiting
UC San Diego HealthLa Jolla, California, United StatesRecruiting
Stanford UniversityStanford, California, United StatesRecruiting
Colorado Blood Cancer InstituteDenver, Colorado, United StatesRecruiting
Yale UniversityNew Haven, Connecticut, United StatesRecruiting
Baptist Health Miami Cancer InstituteMiami, Florida, United StatesRecruiting
Winship Cancer Institute of Emory UniversityAtlanta, Georgia, United StatesRecruiting
Georgia Cancer Center at Augusta UniversityAugusta, Georgia, United StatesRecruiting
Robert H Lurie Cancer CenterChicago, Illinois, United StatesRecruiting
University of Kansas Cancer CenterWestwood, Kansas, United StatesRecruiting

+ 20 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04792489