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Study identifier: NCT04791384 Synced from ClinicalTrials.gov · July 28, 2026
● Terminated

Phase Ib/II Trial of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer

Condition: Breast Cancer  ·  Sponsor: Criterium, Inc.

PhasePhase 1/Phase 2
Planned participants5
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multi-institutional, single arm, open label, Phase Ib/II study of abemaciclib in combination with elacestrant in patients with HR+/Her2- breast cancer metastatic to the brain. Patients may have received up to two prior lines of systemic chemotherapy for locally advanced or metastatic disease. There will be no limit on prior use of endocrine therapy including aromatase inhibitors, tamoxifen and fulvestrant, given a documented clinical benefit of elacestrant in this setting.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (4)

University of ColoradoAurora, Colorado, United States
Mount Sinai Comprehensive Cancer CenterMiami Beach, Florida, United States
Duke Cancer CenterDurham, North Carolina, United States
Cancer Care NorthwestSpokane Valley, Washington, United States

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Source record: clinicaltrials.gov/study/NCT04791384