Condition: Interstitial Lung Disease · COPD · Pulmonary Arterial Hypertension · Sponsor: Bastiaan Driehuys
The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH's unique 129Xe MRI signature has been shown in previous studies. Past studies have lacked a pathologic "ground truth" correlate of these signatures, which could be provided by comparing them with the pathology of lung explant tissue from patients who have undergone a lung transplant. This signature could be validated in a cohort of patients with Group 3 PH in future studies.
This description comes directly from the study's public registry record.
Claudia Salazar · +1 919 660 2026 · claudia.salazar@duke.edu
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| Duke University Medical Center | Durham, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04778046