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Study identifier: NCT04762134 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO)

Condition: Bacterial Sexually Transmitted Diseases  ·  Sponsor: Jonathan Troy Grennan

PhaseNA
Planned participants560
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

There is a growing epidemic of the bacterial sexually transmitted infections (STIs) syphilis, chlamydia and gonorrhea worldwide; similarly concerning trends have been noted in Canada, where increases of over 160% have been seen in bacterial STIs over the last decade. In Canada, gay, bisexual, and other men who have sex with men (gbMSM) - including those living with HIV - are disproportionately impacted by bacterial STIs5,6These dramatic increases in bacterial STIs, the potential development of serious complications including AMR, and waning effectiveness of the promotion of conventional STI prevention tools (e.g. condoms), signals the need for novel STI prevention strategies and tools to mitigate STI-related complications. A rigorous randomized controlled trial will be conducted to compare STI PrEP vs. STI PEP and definitively assess the efficacy, safety, antimicrobial resistance profiles and costs associated with doxycycline-based STI prevention.

This description comes directly from the study's public registry record.

Talk to the study team

Saira Mohammed  ·  6047542171  ·  smohammed@bccfe.ca

Troy Grennan  ·  6047075606  ·  troy.grennan@bccdc.ca

Always discuss trial participation with your own doctor first.

Locations (6)

Sheldon Chumir CentreCalgary, Alberta, CanadaRecruiting
BC Centre for Disease ControlVancouver, British Columbia, CanadaRecruiting
St. Joseph's Healthcare HamiltonHamilton, Ontario, CanadaNot Yet Recruiting
The Ottawa HospitalOttawa, Ontario, CanadaNot Yet Recruiting
St. Michael's HospitalToronto, Ontario, CanadaRecruiting
McGill University Health CentreMontreal, Quebec, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT04762134