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Study identifier: NCT04754854 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Reduction of Blood Recirculation in Veno-Venous ECMO

Condition: Extracorporeal Membrane Oxygenation · Acute Respiratory Distress Syndrome  ·  Sponsor: Charite University, Berlin, Germany

PhaseN/A
Planned participants136
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf). Theoretically, the optimization of ECMO blood flow is possible using Rf measurements. A prospective, observational study will be performed measuring the Rf of total ECMO blood flow in patients with acute respiratory distress syndrome (ARDS) on V-V ECMO with an ultrasound dilution technique. ECMO blood flow will be optimized by reducing ECMO blood flow in accordance with the measured Rf as long as systemic oxygenation is not compromised.

This description comes directly from the study's public registry record.

Talk to the study team

Steffen Weber-Carstens, Prof. Dr. med.  ·  0049-30450651005  ·  steffen.weber-carstens@charite.de

Martin Russ, Dr. med.  ·  0049-30450651268  ·  martin.russ@charite.de

Always discuss trial participation with your own doctor first.

Locations (1)

Charité - Universitätsmedizin Berlin, Campus Virchow KlinikumBerlin, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT04754854