Condition: Hypertension · Left Ventricular Hypertrophy · Left Ventricular Dysfunction · Sponsor: Wake Forest University Health Sciences
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, vasculature, and brain. Recruiting children with a new hypertension diagnosis over a 2-year period from the Hypertension and Pediatric Nephrology Clinics affiliated with Brenner Children's Hospital at Atrium Health Wake Forest Baptist and Atrium Health Levine Children's Hospital. Healthy control participants will be recruited from local general primary care practices. Collecting blood and urine samples to analyze components of the renin-angiotensin-aldosterone system (Ang-(1-7), ACE2, Ang II, ACE), uric acid, and klotho, and measuring blood pressure, heart structure and function, autonomic function, vascular function, and kidney function at baseline, year 1, and year 2. Objectives are to investigate phenotypic and treatment response variability and to causally infer if Ang-(1-7), ACE2, Ang II, ACE, uric acid, and klotho contribute to target organ injury due to hypertension.
This description comes directly from the study's public registry record.
Andrew M South, MD, MS · 336.716.9640 · asouth@wakehealth.edu
Caroline B Lucas · 336.713.8038 · cblucas@wakehealth.edu
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| Wake Forest Health Sciences | Winston-Salem, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04752293