Condition: Ulcerative Colitis · Sponsor: Centre Hospitalier Universitaire, Amiens
An increased risk of cardiovascular (CV) diseases has been observed in patients with inflammatory bowel diseases (IBD). The impact of IBD drugs, such as anti-TNF, anti-integrins or anti-JAK, on the risk of CV events in IBD is remains unknown. Aortic pulse wave velocity (aPWV), a measure of aortic stiffness, and carotid intima media thickness (CIMT) are both predictors of cardiovascular events and are increased in patients with IBD. The investigators aimed to prospectively compare the CV risk, CIMT, arterial stiffness and biomarkers of endothelial dysfunction at baseline and after 3 and 12 months of anti-TNF, vedolizumab and tofacitinib.
This description comes directly from the study's public registry record.
Mathurin Fumery, Pr · 03 22 08 88 51 · Fumery.mathurin@chu-amiens.fr
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| CHU Amiens | Amiens, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04743518