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Study identifier: NCT04740424 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

FS222 First in Human Study in Patients With Advanced Malignancies

Condition: Advanced Cancer · Metastatic Cancer  ·  Sponsor: invoX Pharma Limited

PhasePhase 1
Planned participants260
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will be conducted in adult participants diagnosed with advanced tumours to characterize the safety, tolerability, pharmacokinetics (PK), and activity of FS222. This is a Phase 1, multi-center, open label, multiple-dose, first in human study, designed to systematically assess safety and tolerability, and to identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) for FS222 in participants with advanced tumours. Pharmacokinetics, pharmacodynamics, immunogenicity, and response will also be assessed.

This description comes directly from the study's public registry record.

Talk to the study team

invoX Clinical Trials  ·  +44 2038 820886  ·  info@invoxpharma.com

Always discuss trial participation with your own doctor first.

Locations (21)

Calvary Mater NewcastleWaratah, New South Wales, AustraliaRecruiting
One Clinical Research PerthPerth, Western Australia, AustraliaRecruiting
Arensia Exploratory Medicine, LLCTbilisi, GeorgiaRecruiting
SLK Kliniken Heilbronn GmbHHeilbronn, Baden-Wurttemberg, GermanyRecruiting
Radboud Universitair Medisch CentrumNijmegen, Gelderland, NetherlandsRecruiting
Centrum Medyczne Poznan - PRATIA - PPDSPoznan, Greater Poland Voivodeship, PolandRecruiting
MCM Krakow - PRATIA - PPDSKrakow, PolandRecruiting
Prof. Dr. Alexandru Trestioreanu Oncologic InstituteBucharest, RomaniaRecruiting
Prof Dr I Chiricuta Institute of OncologyCluj-Napoca, RomaniaRecruiting
Clinica Universidad NavarraPamplona, Navarre, SpainRecruiting
NEXT - Hospital Quironsalud BarcelonaBarcelona, SpainRecruiting
Hospital Universitari Vall D'HebronBarcelona, SpainRecruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04740424