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Study identifier: NCT04739358 Synced from ClinicalTrials.gov · July 28, 2026
● Terminated

CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC

Condition: Advanced Non-Small Cell Lung Cancer With MET Mutations  ·  Sponsor: Criterium, Inc.

PhasePhase 1/Phase 2
Planned participants2
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will look at how effective the study drug (tepotinib) is at stopping the growth and spread of lung cancer with central nervous system metastasis. In some patients, who have developed resistance to their tyrosine kinase inhibitors (TKIs), this study will look at how effective tepotinib is in combination with TKIs. This study will also measure a number of other things including safety of the study drug and the side effects, how body processes the study drug, or how the study drug affects your quality of life.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (5)

UC Davis Comprehensive Cancer CenterSacramento, California, United States
University of Colorado Cancer CenterAurora, Colorado, United States
Georgetown Lombardi Comprehensive Cancer CenterWashington D.C., District of Columbia, United States
UPMC Hillman Cancer CenterPittsburgh, Pennsylvania, United States
University of WashingtonSeattle, Washington, United States

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Source record: clinicaltrials.gov/study/NCT04739358