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Study identifier: NCT04728893 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Condition: Hematologic Malignancies · Waldenstroms Macroglobulinaemia · Non-Hodgkins Lymphoma  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2
Planned participants490
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (121)

Highlands Oncology Group ( Site 2728)Springdale, Arkansas, United StatesRecruiting
University of California San Diego Moores Cancer Center ( Site 2717)La Jolla, California, United StatesRecruiting
Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724)Torrance, California, United StatesCompleted
Colorado Blood Cancer Institute ( Site 2726)Denver, Colorado, United StatesRecruiting
The University of Louisville, James Graham Brown Cancer Center ( Site 2729)Louisville, Kentucky, United StatesCompleted
Mayo Clinic - Rochester ( Site 2706)Rochester, Minnesota, United StatesActive Not Recruiting
Astera Cancer Care ( Site 2732)East Brunswick, New Jersey, United StatesRecruiting
John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704)Hackensack, New Jersey, United StatesRecruiting
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708)Fargo, North Dakota, United StatesCompleted
UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730)Dallas, Texas, United StatesRecruiting
Medical Oncology Associates (Summit Cancer Centers) ( Site 2710)Spokane, Washington, United StatesRecruiting
Hospital Aleman ( Site 0102)Ciudad Autonoma de Buenos Aires, Buenos Aires, ArgentinaRecruiting

+ 109 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04728893