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Study identifier: NCT04724018 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sacituzumab Govitecan Plus EV in Metastatic UC

Condition: Urothelial Cancer · Metastatic Urothelial Carcinoma · Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 1/Phase 2
Planned participants106
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Phase I of this research study will assess what doses of Sacituzumab Govitecan and Enfortumab Vedotin can be safely combined in the treatment of metastatic urothelial carcinoma (mUC). In Phase II of the study, patients in one of the two cohorts will receive Sacituzumab Govitecan, Enfortumab Vedotin, and Pembrolizumab to assess the efficacy of this drug combination. The names of the study drugs in these investigational combinations are: * Enfortumab Vedotin * Sacituzumab Govitecan * Pembrolizumab

This description comes directly from the study's public registry record.

Talk to the study team

Bradley A McGregor, MD  ·  617-632-1914  ·  Bmcgregor@partners.org

Merdith Flynn  ·  617-632-5701  ·  Meredith_Flynn@DFCI.HARVARD.EDU

Always discuss trial participation with your own doctor first.

Locations (1)

Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04724018