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Study identifier: NCT04722692 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ

Condition: DCIS · Breast Cancer · Breast Neoplasms  ·  Sponsor: Uppsala University

PhasePhase 3
Planned participants500
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The trial aims to investigate the use of superparamagnetic iron oxide (SPIO) nanoparticles as a tracer for delayed sentinel lymph node dissection (d-SLND) in patients where upfront axillary surgery (SLND) is oncologically deemed unnecessary and should be avoided. This includes but is not limited to patients with a preoperative diagnosis of ductal cancer in situ of the breast (DCIS), an unclear BIRADS 4-5 planned for diagnostic excision or women planned for risk reducing mastectomy. SPIO is injected in the primary operation, and should final specimen pathology demonstrate invasive breast cancer, only then is an operation in the axilla (d-SLND) performed.

This description comes directly from the study's public registry record.

Talk to the study team

Andreas Karakatsanis, PhD  ·  +46765864826  ·  andreas.karakatsanis@surgsci.uu.se

Fredrik Wärnberg, PhD  ·  fredrik.warnberg@vgregion.se

Always discuss trial participation with your own doctor first.

Locations (9)

Baylor College Of MedicineHouston, Texas, United StatesRecruiting
The University of Hong Kong-Shenzhen HospitalHong Kong, Hong KongRecruiting
Falun LasarettFalun, Dalarna County, SwedenRecruiting
Växjö County HospitalVaxjo, Kronoberg County, SwedenRecruiting
Skåne University HospitalLund, Skåne County, SwedenRecruiting
Västmanland County HospitalVästerås, Västmanland County, SwedenRecruiting
Sahlgrenska University HospitalGothenburg, Västra Götaland County, SwedenRecruiting
Uppsala University HospitalUppsala, SwedenRecruiting
Linköping University HospitalLinköping, Östra Götaland, SwedenRecruiting

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Source record: clinicaltrials.gov/study/NCT04722692